First-generation Grubbs catalyst

It is synthesized from RuCl₂(PPh₃)₃, phenyldiazomethane, and tricyclohexylphosphine in a one-pot synthesis.

Second-generation catalyst

The second-generation catalyst has the same uses in organic synthesis as the first generation catalyst, but generally with higher activity. This catalyst is stable toward moisture and air, thus is easier to handle in the lab.

Hoveyda–Grubbs catalysts

First-generation Hoveyda–Grubbs catalyst

Second-generation Hoveyda–Grubbs catalyst

The Hoveyda–Grubbs catalysts, while more expensive and slower to initiate than the Grubbs catalyst from which they are derived, are popular because of their improved stabilit.