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Stobbe condensation

(2022-12-15 19:59:52) 下一个

The Stobbe condensation is a modification specific for the diethyl ester of succinic acid requiring less strong bases. An example is its reaction with benzophenone:

Stobbe condensation

reaction mechanism that explains the formation of both an ester group and a carboxylic acid group is centered on a lactone intermediate (5):

Stobbe condensation mechanism

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