RS cell

Bimodal age distribution: 15-35; >55

painless enlarged lymph node, cervical or supraclavicular

fatigue, fever, night sweats, weight loss, generalized pruritis and splenomegaly

Staging:

Stage I: single Ln or single extralymphatic site

Stage II: 2 or more Lns on the same side of diaphram, or 1 Ln and one contagious extralymphatic site

Stage III: Lns on both sides of the diaphram, which may include the spleen and/or

Stage IV: disisseminated involvement of one or more extralymphatic organs