主演：刘钧 王挺 赵芮 于月仙 解昕恰
本剧讲述了张家口巨商王瑞昌在张库大道上的经商奋斗的故事，再现了时局动荡下这条中国北方唯一的进出口贸易陆路通道的兴衰史。
年满18岁的王瑞昌随舅舅赴张家口经商，孙家镖局为其押货。镖局逆子马戎暗中相好、劫镖之事败露后，马戎逃出孙家当上土匪头目。
王瑞昌立志经商发达，光耀门相。他到成记皮行学做皮货生意，从最底层做起，虽吃了不少苦，但却学到了一身真本事。
为了将皮行的生意做得更大，王瑞昌不畏路途艰险，决定亲自跟随“德盛隆”商号远走库伦。此时马戎却率令众土匪袭击王瑞昌的家，强奸了孙承霞，并将周一龙掳走。王瑞昌从库伦满载而归，孙承霞却发现自己怀上了马戎的孽种。她自觉对不住王瑞昌，却有苦难言，在痛苦犹豫中生下儿子孝鑫。
十三响教唆孙承贵偷光了成记皮行的钱，并将其父孙大成毒死。十三响的养女杏花不愿受孙承贵凌辱，向王瑞昌求助，王瑞昌将她带回家中。
为了东山再起，王瑞昌独自远走库伦，杨伯雷买通马戎，命他干掉王瑞昌和李望达。在二人性命攸关之际，孙承霞兄弟及时相救，马戎再次逃脱……
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